Some of CBD oil's side effects can be dangerous if you do not understand the Cytochrome P System. Discover which drugs are dangerous to combine with . CBD is a very promising new treatment method for many different conditions. Like any other treatment, though, there can be interactions with other meds. OTHER NAME(S). 2-[(1R,6R)Methylpropenylcyclohexenyl] pentylbenzene-1 ,3-diol, CBD. . Show More · Read Reviews (47).
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People take cannabidiol by mouth for anxiety, bipolar disorder, diabetes, a muscle disorder called dystonia, seizures, multiple sclerosis, Parkinson's disease, Crohn's disease, graft-versus-host-disease, and schizophrenia. People inhale cannabidiol to help quit smoking. A specific cannabidiol product Epidiolex, GW Pharmaceuticals has been shown to reduce seizures in adults and children with various conditions that are linked with seizures.
This product is a prescription drug for treating seizures caused by Dravet syndrome or Lennox-Gastaut syndrome. It has also been shown to reduce seizures in people with tuberous sclerosis complex, Sturge-Weber syndrome, and febrile infection-related epilepsy syndrome FIRES. But it's not approved for treating these other types of seizures. Insufficient evidence to rate effectiveness for Early reports show that taking cannabidiol does not improve manic episodes in people with bipolar disorders.
Early research shows that taking cannabidiol does not reduce disease activity in adults with Crohn's disease. Early research shows that taking cannabidiol does not improve blood glucose levels, blood insulin levels, or HbA1c in adults with type 2 diabetes. A muscle disorder called dystonia.
Higher quality research is needed to confirm this. Graft-versus-host disease is a complication that can occur after a bone marrow transplant. In people with this condition, donor cells attack the person's own cells. Early research shows that taking cannabidiol daily starting 7 days before bone marrow transplant and continuing for 30 days after transplant can extend the time it takes for a person to develop GVHD.
Early research shows that taking cannabidiol daily does not improve symptoms of Huntington's disease. Early research suggests that taking mg of cannabidiol before bed improves sleep time in people with insomnia. However, lower doses do not have this effect. Cannabidiol also does not seem to help people fall asleep and might reduce the ability to recall dreams.
There is inconsistent evidence on the effectiveness of cannabidiol for symptoms of multiple sclerosis. Some early research suggests that using a cannabidiol spray under the tongue might improve pain and muscle tightness in people with MS.
However, it does not appear to improve muscle spasms, tiredness, bladder control, the ability to move around, or well-being and quality of life.
Some early research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson's disease and psychosis. Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is conflicting.
Some early research suggests that taking cannabidiol four times daily for 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. However, other early research suggests that taking cannabidiol for 14 days is not beneficial. The conflicting results might be related to the cannabidiol dose used and duration of treatment. Some early research shows that taking cannabidiol mg daily does not improve anxiety in people with social anxiety disorder.
However, other early research suggests that taking a higher dose mg may improve anxiety associated with public speaking or medical imaging test in people with SAD.
More evidence is needed to rate the effectiveness of cannabidiol for these uses. Cannabidiol has antipsychotic effects. The exact cause for these effects is not clear. However, cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function.
Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia.
Cannabidiol might also block some of the psychoactive effects of deltatetrahydrocannabinol THC. Also, cannabidiol seems to reduce pain and anxiety.
Cannabidiol in doses of up to mg daily have been taken by mouth safely for up to 6 months. Higher doses of mg daily have been taken by mouth safely for up to 4 weeks.
Cannabidiol sprays that are applied under the tongue have been used in doses of 2. Some reported side effects of cannabidiol include dry mouth, low blood pressure, light headedness, and drowsiness.
Signs of liver injury have also been reported in some patients, but this is less common. There is not enough reliable information about the safety of taking cannabidiol if you are pregnant or breast feeding.
Stay on the safe side and avoid use. This product is approved for use in certain children 2 year of age and older, but has been used in children as young as 1 year of age. Major Do not take this combination. Clobazam Clobazam is changed and broken down by the liver.
Cannabidiol might decrease how quickly the liver breaks down clobazam. This might increase the effects and side effects of clobazam. Valproic acid Valproic acid can cause liver injury. Taking cannabidiol with valproic acid might increase the chance of liver injury. Moderate Be cautious with this combination. Eslicarbazepine Eslicarbazepine is changed and broken down by the body. Cannabidiol might decrease how quickly the body breaks down eslicarbazepine.
This might increase levels of eslicarbazepine in the body by a small amount. Cannabidiol might decrease how quickly the liver breaks down some medications. In theory, using cannabidiol along with some medications that are broken down by the liver might increase the effects and side effects of some medications.
Before using cannabidiol, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications changed by the liver include chlorzoxazone Lorzone and theophylline Theo-Dur, others. Some medications changed by the liver include amitriptyline Elavil , haloperidol Haldol , ondansetron Zofran , propranolol Inderal , theophylline Theo-Dur, others , verapamil Calan, Isoptin, others , and others.
Some medications changed by the liver include theophylline Theo-Dur, others , omeprazole Prilosec, Omesec , clozapine Clozaril, FazaClo , progesterone Prometrium, others , lansoprazole Prevacid , flutamide Eulexin , oxaliplatin Eloxatin , erlotinib Tarceva , and caffeine.
Some medications changed by the liver include nicotine, chlormethiazole Heminevrin , coumarin, methoxyflurane Penthrox , halothane Fluothane , valproic acid Depacon , disulfiram Antabuse , and others. Some medications changed by the liver include ketamine Ketalar , phenobarbital, orphenadrine Norflex , secobarbital Seconal , and dexamethasone Decadron. Some medications changed by the liver include proton pump inhibitors including omeprazole Prilosec , lansoprazole Prevacid , and pantoprazole Protonix ; diazepam Valium ; carisoprodol Soma ; nelfinavir Viracept ; and others.
Some medications changed by the liver include nonsteroidal anti-inflammatory drugs NSAIDs such as diclofenac Cataflam, Voltaren , ibuprofen Motrin , meloxicam Mobic , and piroxicam Feldene ; celecoxib Celebrex ; amitriptyline Elavil ; warfarin Coumadin ; glipizide Glucotrol ; losartan Cozaar ; and others. Some medications changed by the liver include amitriptyline Elavil , codeine, desipramine Norpramin , flecainide Tambocor , haloperidol Haldol , imipramine Tofranil , metoprolol Lopressor, Toprol XL , ondansetron Zofran , paroxetine Paxil , risperidone Risperdal , tramadol Ultram , venlafaxine Effexor , and others.
Some medications changed by the liver include alprazolam Xanax , amlodipine Norvasc , clarithromycin Biaxin , cyclosporine Sandimmune , erythromycin, lovastatin Mevacor , ketoconazole Nizoral , itraconazole Sporanox , fexofenadine Allegra , triazolam Halcion , verapamil Calan, Isoptin and many others.
Some medications changed by the liver include testosterone, progesterone Endometrin, Prometrium , nifedipine Adalat CC, Procardia XL , cyclosporine Sandimmune , and others. Rufinamide Rufinamide is changed and broken down by the body. Cannabidiol might decrease how quickly the body breaks down rufinamide. This might increase levels of rufinamide in the body by a small amount. Sedative medications CNS depressants Cannabidiol might cause sleepiness and drowsiness.
Medications that cause sleepiness are called sedatives. Taking cannabidiol along with sedative medications might cause too much sleepiness. Some sedative medications include benzodiazepines, pentobarbital Nembutal , phenobarbital Luminal , secobarbital Seconal , thiopental Pentothal , fentanyl Duragesic, Sublimaze , morphine, propofol Diprivan , and others.
Topiramate Topiramate is changed and broken down by the body. Cannabidiol might decrease how quickly the body breaks down topiramate. This might increase levels of topiramate in the body by a small amount. Zonisamide Zonisamide is changed and broken down by the body. Cannabidiol might decrease how quickly the body breaks down zonisamide. This might increase levels of zonisamide in the body by a small amount. Herbs and supplements with sedative properties Cannabidiol can cause sleepiness or drowsiness.
Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John's wort, sassafras, skullcap, and others. There are no known interactions with foods. The following doses have been studied in scientific research: A prescription cannabidiol product Epidiolex has been used.
The recommended starting dose is usually 2. Thank you for your question. Please speak to your doctor before using CBD. Best of luck to you. Out of all the questions people have asked you seem to have the same answer. So tell me what is the purpose of your site. But I will always help as much as I can, with product related questions mostly. No, you should not have to worry about any interaction with a medication you are taking since the topical CBD from the massage is not entering your bloodstream.
The only interaction to be possibly concerned with is with something else you are using on your skin, though I never heard of anyone having a problem with this. Please speak to a doctor or pharmacist who can help you get that answered. My pain killers do not work.
I am also diabetic on Metformin. I am desperate to have less continuous pain. What can I do? I agree with your doctor. It would be best to speak with your pharmacist as they know all of your current medications. You pharmacist and doctor may also want to monitor you while you take the CBD to make sure there are no negative interactions with the medications you are currently taking.
Thank you for sharing such a important information, as rarely people know this use of CBD. We advise speaking to a doctor before starting. The problem is that CBD can alter the normal way your body processes the Warfarin, thereby changing its effects. Please speak with your doctor before using CBD if you are taking Warfarin. Your doctor may want to monitor you closely if you decide to use CBD to make sure there are no issues with a drug interaction. I take two meds for prostate ,desmopressin tab and finasteride tab.
I have arthritis and was thinking about cbd for pain. What kind of medicine do you mean when you say water pills? We recommend you speak with your doctor or pharmacist before mixing in CBD with your other medications. Hi I had a disc fusion level 2 years ago and have been left with chronic pain in my neck which no medication seems to relieve I am on 3 different medications one being diazepam do you think I could try hemp oil while using these drugs Any information would be very useful to me Thanks Debbie.
There is a possibility for a drug interaction between CBD and your other medications. I urge you to check with your doctor first as they may want to monitor your blood levels of other medications you are on.
Project CBD just released an excellent paper on drug interactions which you should download and check out. Hi thanks for your question.
Project CBD has also released a new report on drug interaction for which we highly recommend you check out.
Visit Project CBD to download the report. Can I buy book I am not professional I have some concern medicaltion issue with cbd oil interact issue thank you. Click here to check out our article about the best books on CBD. Please let us know if you have other questions. We recommend you check that out over at the Project CBD website. CBD may interact with pain medications.
Some people find this interaction beneficial because it allows them to take less of their opiate medications and avoid side effects and addiction to the opiate pain killers. Still I recommend you speak with a doctor and your pharmacist first, before using CBD. I also recommend you review the brand new report just published over at Project CBD on drug interactions.
You can go to the Project CBD website and download it for free. Let me know if you have more questions please. Unfortunately we at CBD School do not have the medical background to answer specific questions. My recommendation is to speak to a doctor or pharmacist for this specific inquiry. Can I safely take CBD oil with these prescription drugs: I have been sober for over 25 years. Which is the primary trigger of my PTSD.
Will it get me high? Thanks for your comment and question. CBD is non-addictive and non-intoxicating. Many people report that CBD does help with their pain. A more concentrated CBD product example would be a tincture or a capsule. I recommend you speak with a medical professional who knows your current medications before you start using CBD.
I am currently taking 2. My recommendation is to speak to a doctor or pharmacist for this specific inquiry about this medication and CBD.
My recommendation is to speak to your doctor or a pharmacist for this specific inquiry about this medication and CBD. Thanks for your feedback. We always recommend checking with your doctor before starting to use CBD, especially if you are taking other medications already.
Hi can u take cbd. Many people do find that CBD helps them be less anxious. There are indeed some theories that CBD may have to build up in your system to get the most benefits. However I have never seen any evidence for this. Any known drug interactions with these and CBD oil? Unfortunately we at CBD School do not have the medical background to answer specific questions like the one you asked.
I have a friend who has the autoimmune condition Lupus, and wanted to try CBD oil to treat it. I got him a bottle, but he was reluctant to take it because: He wanted to discuss the issue with his doctor, but keeps forgetting to mention the issue during his last visit.
The oil that I got for him was mixed with coconut oil, which he is allergic to because of his Lupus condition. He told me that he takes Warfarin, and is concerned about possible interactions with it.
What should I advise him. Would CBD oil be appropriate for him? Thanks for your great questions. I answered your questions below. Please write me back if you have more! Yes, he absolutely needs to discuss this with his doctor first. There are plenty of CBD products out there without coconut oil. Bluebird Botanicals CBD tincture is just one example. They use hemp seed oil instead of coconut oil. He absolutely needs to check with his doctor first.
The doctor may request to monitor his blood levels while he takes the CBD to make sure there is no negative interaction with Warfarin.
Please be careful about this. Always talk to the doctor before starting CBD. This would be good to show his doctor. Unfortunately as much as our mission is to do our best to get all your CBD questions answered, we at CBD School do not have the medical background to answer specific questions like the one you asked. The drug interactions which have been studied all occurred when CBD was ingested internally into the body. Hope that answers your question.
My recommendation is to definitely speak to your doctor or a pharmacist for this specific inquiry about using Xanax with CBD. I found I felt a bit weird, a bit woozy and tired after the third day. I take amlodipine for high blood pressure, levothyroxin for underactive thyroid and ibuprofen and paracetamol for the pain.
Would CBD have this effect? I have been told to avoid grapefruit when taking amlodipine. This is a serious matter and you need to seek the advice of a medical professional like a doctor or pharmacist. While we strive to do our best to answer as many questions as we can, we cannot help with medical questions like this. I have late on set Asthma. The GP has found this to be difficult to control with normal inhalers and now I take alot of medication. The main drug I take is sterroids and this drug has many side effects if taken over a long time are numerous and life long.
Its very hard to explain the pain associated with Brittle Bones and other conditions associated with sterroids. I took the sterroids over 20years. I take this in 2 ways mg and 25mg fenanil patches and the rest topped up with oralmorph at regular intervals daily. I also take nefopam and paracetamol.
I know all the complications like addiction and more from morphine and other pain meds. I want them to stop and go back to the person I used to be. I need to know the drug interactions so I can take CBD effectively. Would u like me to right Down the list of meds or would it be easier to show me the list CBD interacts with. I think it would be a lot smaller than my list of meds. However we are not able to provide medical advice.
In your situation I would recommend you seek out the help of a cannabis clinic and doctor who is able to provide medical advice for your specific condition and the use of CBD and cannabis. Ok, These are my regular everyday drugs that I take. Please tell me if you see any problems with me using CBD and these medications. My major health issues are Rhumitoid Arthritis, Fibromyalgia, Osteoarthritis and my disc are collapsing. My recommendation is to speak to your doctor or a pharmacist for this specific inquiry about your medication and CBD.
I have never used CBD oil, are they all equal? Are some brands more effective and safer than others? There are many CBD brands on the market offering a wide variety of products. Most brands differ in their product line and speciality items. It all depends on what you are looking for. For safe products, you want to find a brand which provides you with good customer support and up-to-date lab reports for their full product line.
They should provide them to you. We have some of our favorite brands listed here and you can also check out the reviews section of the site. Hello could you please tell me where I can find the listing of drugs that interact with CBD? Please take a look at this link. Let us know if you found it helpful as we are trying to find the right places to send our site visitors to for the best information on CBD drug interactions.
Can a person on blood thinners use CBD oil topically without complications internally? I recommend you still check this with your doctor or pharmacist but I see no issues with a drug interaction when using a topical CBD product like a balm or cream.
Those would possibly be a concern though I have never heard of someone having a drug interaction from those. If you are using CBD cream or balm, I do not see this as a problem. Of course we always recommend you get the final OK from a doctor or medical professional. Since we are not able to provide medical advice or answer medical questions, we encourage everyone to consult their doctor about their questions before using CBD.
Can I take cbd oil with Lipitor. Lipator and take cbd oil twice a day. Here is another good resource to check out as well. Please address taking CBD oil and anti-depressants. Please address taking CBD oil and opioids or painkillers.
For example, I believe that the CBD oil renders the opioids virtually useless. Thanks for your great question. We at CBD School are not able to provide advice of this kind as we have no medical background. Please speak with your doctor and pharmacist about this. I asked some questions to a woman that uses it and sells it and I purchased it right away!! In week 1 already saw the Enormous difference!!
Pain is pretty much Gone!!! Probably knowing it has some THC in it he joked with me and picked it up and pretended to drink it all but otherwise he said nothing about it!!
Obviously I am on many Meds Prescribed from him and he is a young Physician Assistant and is pretty cool!! I used to be Prescribed 3 extended release Morphine 30mg but after the Law came out awhile ago the Dr.
Well I recently left Pain Management and weaned myself off the Morphine it did nothing anyway!! When I went to my Internal Medicine Dr. So what do I do?? We are not able to provide any medical advice. I wish to get away from the opiates. Are you aware of products to help accomplish this?
We completely understand why you want to get away from opiates. We are not able to provide any medical advice here at CBD School. Overall, drawing a conclusion based on available research is subject to interpretation and personal biases. The same studies can be interpreted positively or negatively, depending on your perspective. On the one hand, studies have provided compelling evidence that alcohol increases blood THC levels although no evidence suggests the converse—that THC increases blood alcohol levels.
On the other hand, some research suggests people consume less alcohol when they use cannabis. In fact, they make sense. If THC reacts to alcohol by potentiating the desired effects on mood, then one would need less alcohol. Concordance of Use by Men and Women , that examined consumption pattern differences in three different environments only alcohol is available, only cannabis is available, both are available.
Basically, when people have access to both substances, their consumption patterns change: That being said, one still needs to be cautious. For one, alcohol and cannabis together pose even greater dangers driving than when using either one independently. Second, if someone has had too much to drink—to the point they need to vomit to expel the toxins—know that cannabis inhibits nausea and vomiting. Many sedatives—such as alcohol, benzodiazepines Ativan, Valium, etc. Although, each of these compounds produce effects differently, and sometimes paradoxically.
For example, higher doses of THC can actually be stimulating and increase anxiety, while CBD can be both calming or wake-inducing. When combined with sedatives, cannabis produces an additive effect.
Users should exercise extreme caution, or better yet, avoid the combination altogether. Although evidence suggests CBD is largely safe, well-tolerated, and non-addictive even anti-addictive , in some patients it can interact synergistically beneficially or adversely with other medications. Most notably, the interplay between CBD and cytochrome P seems be most prominent when it comes to epilepsy and anti-seizure medications.
One small study published in found that CBD elevated blood concentrations of clobazam an anticonvulsant in children while elevating norclobazam an active metabolite of clobazam. The good news is the remedy seems fairly straightforward: But in short, CBD inhibits breakdown of warfarin a blood thinner , thereby increasing its duration of action and effect. Patients taking CBD-rich products should pay close attention to changes in blood levels and adjust dosage accordingly as instructed by their doctor.
Also, patients who are undergoing chemotherapy and taking CBD should be aware that the same dose of chemotherapy may produce higher blood concentrations.
For most patients, cannabis is relatively safe, well-tolerated, and carries fewer risks of adverse drug interactions than many other commonly prescribed drugs. Influenced by these cannabinoid and terpene profiles, potential interactions, both good and bad, can vary from strain to strain.
Patients should continually monitor the effect.
SPS – Specialist Pharmacy Service - The first stop for professional medicines advice
CBD is a potent inhibitor of CYP3A4 and CYP2D6. ▫ As CYP3A4 metabolizes about a quarter of all drugs, CBD may increase serum concentrations of. CBD-Drugs Interactions. Today we are about to address a quite sensitive issue – the interaction of pharmaceutical drugs and cannabidiol. Although the CBD. A quick guide to follow to avoid complications from CBD drug interactions.