The FDA does not allow us to make any claims about what CBD Hemp Oil can do or . Q7: When using the Vape Oil, how do I know how much CBD I'm getting?. The FDA does not allow us to make any claims about what CBD Hemp Oil can do or. Q7: When using the Vape Oil, how do I know how much CBD I'm getting?. Q7: When using the Vape Oil, how do I know how much CBD I'm getting?. Vaping CBD oil has become increasingly popular over the past few.
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Mar 12, - Vaping CBD can offer almost immediate relief to symptoms ranging from chronic pain to anxiety. However, getting started can be intimidated, Sep 21, - Everything you need to know about vaping CBD oil and the best brands with the most reliable and effective CBD vape juices based on testing Mar 16, - To vape CBD oil, you need a vape pen. You place a few drops of oil on the coils and inhale.
You need a special CBD e-juice for vaping , but this Federal licensed sellers are governed by Health Canada's regulations in order to ensure the quality of their product.
Having Veterans access these products through federal licensed sellers provides the Department the assurance that the product is regulated and controlled, so that the health and well-being of Veterans is always at the forefront. Will there be enough supply of cannabis for medical purposes if everyone can buy cannabis? Veterans should carry a copy of their registration certificate as proof that they can possess a limited amount of cannabis for medical purposes.
Under the Cannabis Act , in public, you may possess the lesser of grams or a day supply of dried cannabis or the equivalent in cannabis product , in addition to 30 grams allowed for non-medical purposes. For more information, visit the Department of Justice website www. Check your provincial or territorial laws to determine what additional administrative penalties may be imposed upon you, in addition to any criminal penalties, for impaired driving where you live.
For more information, visit the Government of Canada website www. My local health care practitioner will not medically authorize cannabis for me, so I have to travel. Does Veterans Affairs Canada reimburse travel costs incurred to obtain the services of a health care practitioner who will medically authorize cannabis for medical purposes? Yes, however you must visit the nearest treating centre to your residence, and the travel must be pre-authorized.
Round trips under km must be pre-authorized by a case manager or Client Service Agent. Round trips over km must be pre-authorized by a Veterans Service Team Manager. You must provide documentation from an appropriate medical specialist. They must have expertise in the condition for which you are medically authorized for cannabis for medical purposes.
Each claim will be reviewed on a case-by-case basis and must explain why more than three grams per day is necessary to treat your condition. Once you submit your paperwork, your file will be reviewed, a decision will be made, and you will be notified in writing of the decision.
In end-of-life situations as defined in the policy , documentation is not required from a medical specialist. Documentation from your specialist should be sent to: For example, a Veteran who has pain from cancer would need to provide medical documentation from an oncologist to request an exceptional approval. A Veteran who is suffering with mental health issues would need to provide medical documentation from a psychiatrist.
Veterans diagnosed with chronic pain and a psychiatric condition only need one medical specialist's rationale. A letter from your medical specialist supporting the use of more than three grams per day has a validity period of two years, provided there is no change in quantity of cannabis being authorized by your treating health care practitioner.
This article focuses on one aspect of pharmaceutical regulation, namely the requirement of a medical prescription for purchasing antibacterials. However, a strategy of deregulation should not only concern the switch from prescription-only status to nonprescription status for a given drug, but should consider some complementary measures to minimise potentially harmful effects on health and costs. Risk-benefit and economic evaluations, which are possible approaches to assess the convenience of antibacterial deregulation , force the empirical evidence, the assumptions, as well as the value judgements on which the options are evaluated, to be made explicit.
We outline the basic traits of an economic-evaluation approach to assess the issues related to the public interest and the feasibility of a deregulation policy. However, the answer cannot be a generic one, but should address the question for each particular country, and for each antibacterial and indication. Given the limitations of existing evidence on that issue, a tentative research agenda is also proposed.
Anaplastic large cell lymphoma ALCL is divided into two systemic diseases according to the expression of the anaplastic lymphoma kinase ALK. The data were validated in primary ALCL cases. CBD spray and MS spasticity symptoms: A randomized, placebo controlled long-term follow-up clinical trial with THC: CBD spray versus placebo demonstrated that it was not associated with cognitive decline, depression or significant mood changes after 12 months of treatment.
CBD oromucosal spray did not adversely influence standard driving ability in patients with moderate to severe MS spasticity. Other new long term observational data about the use of THC: Findings to date reinforce the efficacy and safety observed in Phase III clinical trials.
It is of interest that in practice average dosages used by patients tended to be lower than those reported in clinical studies Thus, these new data support a positive benefit-risk relationship for THC: CBD oromucosal spray during longer-term use. Airline Deregulation and Public Policy. An assessment of the effects of airline deregulation on travelers and carriers indicates that deregulation has provided travelers and carriers with Airport congestion, airline safety, airline bankruptcy, and mergers are also analyzed and found in most cases to have reduced benefits.
But, these costs should not be attributed to deregulation per se, but to failures by the government to pursue appropriate policies in these areas.
Pursuit of policies that promote airline competition and efficient use of airport capacity would significantly increase the benefits from deregulation and would provide valuable guidance for other industries undergoing the transition to deregulation. The report presents an evaluation of the impacts associated with the implementation of fare-free transit service in the Central Business District CBD of Albany, New York.
The Albany demonstration began in November ; fares were eliminated for tr Laparoscopic CBD exploration using a V-shaped choledochotomy. The advantages of this technique are that it is less invasive than conventional open surgery and it permits single-stage management; however, other technical difficulties limit its use. After the confluence of the cystic duct and the CBD were exposed, a V-shaped incision was made along the medial wall of the cystic duct and the lateral wall of the common hepatic duct, which comprise two sides of Calot's triangle.
The choledochoscope was inserted into the lumen of the CBD through a V-shaped incision, and all CBD stones were retrieved using a basket or a Fogarty balloon catheter or were irrigated with saline. After CBD clearance was confirmed using the choledochoscope, the choledochotomy was closed with the bard absorbable suture material known as V-loc.
The mean operative time was All patients recovered without any postoperative complications, except for one patient who developed postoperative pancreatitis. No conversions to laparotomy were observed, and there were no recurrent stones and no need of T-tube insertion. This report suggests that our novel technique, known as V- CBD , may represent a feasible and straightforward procedure for treating choledocholithiasis, especially when the CBD is not dilated.
Corticobasal degeneration with olivopontocerebellar atrophy and TDP pathology: CBD is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, basal ganglia, diencephalon and brainstem, as well as ballooned neurons and astrocytic plaques.
Two patients had clinical features suggestive of progressive supranuclear palsy PSP , and the third case had cerebellar ataxia thought to be due to idiopathic OPCA. Corticobasal degeneration CBD is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, basal ganglia, diencephalon, and brainstem, as well as ballooned neurons and astrocytic plaques.
CBD oromucosal spray in routine clinical practice. Web-based real-time data collection techniques are combined with traditional patients' diaries to capture a wide spectrum of outcomes associated with this innovative cannabis-based medication.
In the Italian cohort, THC: CBD oromucosal spray was added mainly to oral baclofen. Similar to MOVE 2-Germany, during 3 months' observation, treatment discontinuations were limited and patients recorded meaningful improvements on the patient-based numerical rating scale and physician-rated modified Ashworth scale at mean daily doses that were about one-third lower than those used in the RCT.
CBD oromucosal spray within the context of daily management of our patients with MS spasticity. The grazing incidence x-ray diffraction analysis shows all the fabricated CdS films are hexagonally crystallized.
T-tube is a major procedure that prevents complication by biliary decompression, but which is accompanied by complications. Therefore, several procedures such as ENBD, PTBD, and antegrade biliary stent have been attempted, but with controversies as to which procedure is superior.
Also, there are no standard procedures after laparoscopic CBD exploration. We performed this study to ascertain the most appropriate biliary drainage procedure after laparoscopic CBD exploration.
From March to December , patients who underwent Laparoscopic CBD exploration in Gunyang University were included for retrospective analysis. The patients were divided to 4 groups according to type of procedure, and we compared clinical parameters including age and gender, operation time, hospital stay, start of post-operative diet, and complications. There was no difference in age, gender, mean operation time, postoperative diet between the 4 groups.
Hospital stay in the Stent group was shorter than T-tube group. There were more complications in Stent group but no significant statistical difference. One T-tube case was removed easily by choledochoscopy through the T-tube. Three migrated and the impacted stents were removed by additional endoscopy. Perioperative biliary leakage 1 and peritonitis 1 post t-tube removal were resolved by conservative treatment.
T-tube appears to be an appropriate method to patients who are suspected to have remnant CBD stones. Multiple procedures may be performed on a case by case basis such as performing PTBD first in a suspected cholangitis patient.
Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine. A sensitive and specific analytical method for cannabidiol CBD in urine was needed to define urinary CBD pharmacokinetics after controlled CBD administration, and to confirm compliance with CBD medications including Sativex-a cannabis plant extract containing 1: Non-psychoactive CBD has a wide range of therapeutic applications and may also influence psychotropic smoked cannabis effects.
Solid-phase extraction isolated and concentrated analytes prior to GC-MS. Enzyme-hydrolyzed urine specimens exhibited more than a fold CBD concentration increase compared to alkaline and non-hydrolyzed specimens.
This method can be applied for urinary CBD quantification and further pharmacokinetics characterization following controlled CBD administration. A sensitive and specific analytical method for cannabidiol CBD in urine was needed to define urinary CBD pharmacokinetics after controlled CBD administration, and to confirm compliance with CBD medications including Sativex—a cannabis plant extract containing 1: GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC: The cannabis for this programme is grown in a secret location in the UK.
It is expected that the product will be marketed in the US in late The company is investigating their use in three delivery systems, including sublingual spray, sublingual tablet and inhaled but not smoked dosage forms. The technology is protected by patent applications. GW is also developing a specialist security technology that will be incorporated in all its drug delivery systems. This technology allows for the recording and remote monitoring of patient usage to prevent any potential abuse of its cannabis-based medicines.
GW plans to enter into agreements with other companies following phase III development, to secure the best commercialisation terms for its cannabis-based medicines. The drug will be marketed under the Sativex brand name. This agreement also provides Bayer with an option to expand their license to include the European Union and certain world markets.
GW was granted a clinical trial exemption certificate by the Medicines Control Agency to conduct clinical studies with cannabis-based medicines in the UK. The exemption includes investigations in the relief of pain of neurological origin and defects of neurological function in the following indications: Therefore we investigated, in Wistar rats, effects of pulmonary, oral and subcutaneous sc. While cannabinoid serum and brain levels rapidly peaked and diminished after pulmonary administration, sc.
In contrast, oral CBD produced mild hyperlocomotion. In conclusion, oral administration yielded the most pronounced behavioural effects which corresponded to the highest brain levels of cannabinoids. Of central importance was the novel finding that THC can be detected in serum and brain after administration of CBD alone which, if confirmed in humans and given the increasing medical use of CBD -only products, might have important legal and forensic ramifications.
This method also involved the optimization of cannabinoids and their metabolites extraction in order to remove co-eluting phospholipids and increase the sensitivity of the MS detection. After oral administration, the amount of CBD dissolved in olive oil was higher than that absorbed from an ethanolic solution. This could be explained by the protection of lipid excipients towards CBD from acidic gastric juice.
Laparoscopic management of CBD stones: Common bile duct stones CBDS that are seen in the Asian population are very different from those seen in the west. It is not infrequent to see multiple, large, and impacted stones and a hugely dilated CBD. Many of these patients have been managed by open CBD exploration OCBDE , even after the advent of laparoscopic cholecystectomy LC , because these large stones pose significant challenges for extraction by endoscopic retrograde cholangiopancreatography.
This series presents the largest experience of managing CBDS using a laparoscopic approach from Indian subcontinent. Between and , patients with documented CBDS were treated laparoscopically at a tertiary care hospital in New Delhi. Of these, 4 patients were managed through transcystic route and through the transcholedochal route. There were 34 men and women patients with age ranging from 15 to 72 years. The mean size of the CBD on ultrasound was The number of stones extracted varied from 1 to 70 and the size of the extracted stones from 5 to 30 mm.
The average duration of surgery was There were 6 conversions to open procedures, 1 postoperative death 0. Early Radio Policy Reconsidered. In debating the merits of the deregulation of broadcasting, policy makers should be cognizant of the conditions that led originally to that regulation. An examination of 1 the letters and speeches of Secretary of Commerce, Herbert Hoover, the first regulator of broadcasting; 2 the congressional debate over the regulatory issues of monopoly,….
A comparison of the performance of male and female CBD distributors in Peru. This report presents the results of an operations research project to increase male involvement in family planning in Peru. Both programs found it harder to recruit men than women as distributors.
Program supervisors, who were women, were less comfortable with men than with other women, even though there were no differences in distributor compliance with program norms. Male distributors were more likely to serve male clients and sell male methods condoms , while female distributors were more likely to serve female clients and sell female methods pills. Men sold as much or more total couple-years of protection than did women, and they recruited as many or more new acceptors.
Gender was found to exert an impact on method mix independent of other distributor characteristics, such as age, education, marital status, and number of living children. The study suggests that family planning programs can influence method mix and client characteristics by recruiting men as CBD distributors. Thapa, Dinesh; Cairns, Elizabeth A.
Cannabinoids could be a novel clinical therapy for corneal pain and inflammation resulting from ocular surface injury. Neuronal Dysfunction Associated with Cholesterol Deregulation.
Cholesterol metabolism is crucial for cells and, in particular, its biosynthesis in the central nervous system occurs in situ, and its deregulation involves morphological changes that cause functional variations and trigger programmed cell death. The pathogenesis of rare diseases, such as Mevalonate Kinase Deficiency or Smith—Lemli—Opitz Syndrome, arises due to enzymatic defects in the cholesterol metabolic pathways, resulting in a shortage of downstream products.
The most severe clinical manifestations of these diseases appear as neurological defects. Expanding the knowledge of this biological mechanism will be useful for identifying potential targets and preventing neuronal damage. Several studies have demonstrated that deregulation of the cholesterol pathway induces mitochondrial dysfunction as the result of respiratory chain damage.
We set out to determine whether mitochondrial damage may be prevented by using protective mitochondria-targeted compounds, such as MitoQ, in a neuronal cell line treated with a statin to induce a biochemical block of the cholesterol pathway. Evidence from the literature suggests that mitochondria play a crucial role in the apoptotic mechanism secondary to blocking the cholesterol pathway. Our study shows that MitoQ, administered as a preventive agent, could counteract the cell damage induced by statins in the early stages, but its protective role fades over time.
Pretangles and neurofibrillary changes: Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures.
In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation AD-pretangles , later to form neurofibrillary tangles and finally ghost tangles. This morphological evolution from pretangles to ghost tangles is in parallel with their profile shift from four repeat 4R tau-positive pretangles to three repeat 3R tau-positive ghost tangles with both positive neurofibrillary tangles in between. This complementary shift of tau profile from 4R to 3R suggests that these tau epitopes are represented interchangeably along tangle evolution.
Similar tau immunoreactivity without fibril formation is also observed in corticobasal degeneration CBD -pretangles. CBD -pretangles and AD-pretangles share: However, CBD -pretangles neither evolve into ghost tangles nor exhibit 3R tau immunoreactivity even at the advanced stage.
Because electron microscopic studies on these pretangles are quite limited, it remains to be clarified whether such differences in later evolution are related to their primary ultrastructures, potentially distinct between AD and CBD.
As double staining for 3R and 4R tau clarified complementary shift from 4R to 3R tau along evolution from pretangles to ghost tangles, double immunoelectron microscopy, if possible, may clarify similar profile shifts in relation to each tau fibril at the ultrastructural dimension.
This will provide a unique viewpoint on how molecular epitope representations are related to pathogenesis of fibrillary components. Review of Literature and Case Report. Cortico basal degeneration CBD of the brain is a rare progressive neurodegenerative disease which encompasses unique neuropsychiatric manifestations. Early diagnosis is essential for initiating proper treatment and favorable outcome. Transcranial Magnetic Stimulation TMS , a well-known technique for assessment of cortical excitatory and inhibitory properties.
It was suggested that in a degenerative disease like CBD which involves the cortex as well as the subcortical structures, comparing both hemispheres, a differential pattern in TMS can be obtained which would help in early identification, prognostication and early therapeutic intervention. We describe a case of CBD with corroborative clinical and imaging picture wherein single pulse TMS was used over both the hemispheres measuring the following parameters of interest which included: Differential patterns of MT, CMCT and SP was obtained by stimulating over both the hemispheres with the affected hemisphere showing significantly reduced MT and prolonged CMCT implying early impairment of cortical and subcortical structures thereby revealing the potential application of TMS being utilized in a novel way for early detection and prognostication in CBD syndromes.
Implications for Community College Leaders. Looks at the ways in which the deregulation of business and industry may affect community colleges in the years ahead, using the banking industry as an illustration. Argues that the deregulation of higher education requires that community college leadership programs examine past assumptions and develop new strategies.
Planning For Your Deregulated Future. Colleges and universities can benefit from the coming deregulation of utilities. Deregulation creates opportunity for facility managers to aggressively negotiate agreements, implement changes to the physical plant to make the institution a more attractive customer, and explore new, less expensive energy supply options and alternatives.
Clinical experience with THC: CBD oromucosal spray in patients with multiple sclerosis-related spasticity. Over a month timeframe, THC: CBD spray was initiated in patients. Mean follow-up was 9 months. CBD spray was used as add-on therapy in 95 patients and as monotherapy in 25 patients to achieve best-possible therapeutic results.
CBD spray for less than 60 days. Main reasons for treatment discontinuation were: No new safety signals were noted with THC: CBD spray during the evaluation period. CBD spray was effective and well tolerated as add-on therapy or as monotherapy in a relevant proportion of patients with resistant MS spasticity. Cholecystectomy improves long-term success after endoscopic treatment of CBD stones.
The aim was to study prospectively primary endoscopic treatment of CBD stones and further the long-term need for renewed gallstone disease interventions, defined as short- and long-term outcome. Seven years prospective follow-up of consecutive patients with CBD stones who underwent endoscopic treatment with the intent of primarily achieving duct clearance.
Eleven patients were treated surgically, 2 patients received a permanent stent, and the remaining 3 became stone free with other means. Complications occurred in 47 patients. During follow-up, 31 patients were readmitted for gallstone disease and 15 of these had recurrent CBD stones. Risk factors for new gallstone disease were an in situ gallbladder containing stones and previous episodes of CBD stones.
Subsequent cholecystectomy after duct clearance for CBD should be advised when the gallbladder lodges gallstones, especially in younger patients. Recurrent CBD stones were not influenced by cholecystectomy. A Multicenter Randomized Controlled Trial. Research in both animals and humans indicates that cannabidiol CBD has antipsychotic properties. The authors assessed the safety and effectiveness of CBD in patients with schizophrenia.
In an exploratory double-blind parallel-group trial, patients with schizophrenia were randomized in a 1: These findings suggest that CBD has beneficial effects in patients with schizophrenia. As CBD 's effects do not appear to depend on dopamine receptor antagonism, this agent may represent a new class of treatment for the disorder. MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes.
As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated , contributing to the initiation and maintenance of disease. Deregulation often leads to constitutive overexpression of MYC, which can be achieved through gross genetic abnormalities, including copy number alterations, chromosomal translocations, increased enhancer activity, or through aberrant signal transduction leading to increased MYC transcription or increased MYC mRNA and protein stability.
Herein, we summarize the frequency and modes of MYC deregulation and describe both well-established and more recent findings in a variety of cancer types.
Notably, these studies have highlighted that with an increased appreciation for the basic mechanisms deregulating MYC in cancer, new therapeutic vulnerabilities can be discovered and potentially exploited for the inhibition of this potent oncogene in cancer. Cannabinoid receptors in the brain CB 1 take part in modulation of learning, and are particularly important for working and short-term memory.
Here, we employed a delayed-matching-to-place DMTP task in the open-field water maze and examined the effects of cannabis plant extracts rich in either Delta 9 -tetrahydrocannabinol Delta 9 -THC , or rich in cannabidiol CBD , on spatial working and short-term memory formation in rats.
Delta 9 -THC-rich extracts impaired performance in the memory trial trial 2 of the DMTP task in a dose-dependent but delay-independent manner. Cannabidiol CBD is a plant-derived cannabinoid that has been predominantly characterized as anti-inflammatory. However, it is clear that immune effects of cannabinoids can vary with cannabinoid concentration, or type or magnitude of immune stimulus.
The enhanced inflammatory cell infiltrate as observed in bronchoalveolar lavage fluid BALF was comprised mainly of neutrophils, with some monocytes. These results demonstrate that the CBD -mediated enhancement of LPS-induced pulmonary inflammation is mediated at the level of transcription of a variety of pro-inflammatory genes.
The significance of these studies is that CBD is part of a therapeutic currently in use for spasticity and pain in multiple sclerosis patients, and therefore it is important to further understand mechanisms by which CBD alters immune function. CBD oromucosal spray and others? The complexity of the endocannabinoid eCB system is becoming better understood and new drivers of eCB signaling are emerging.
Modulation of the activities of the eCB system can be therapeutic in a number of diseases. Research into the eCB system has been paralleled by the development of agents that interact with cannabinoid receptors. In this regard it should be remembered that herbal cannabis contains a myriad of active ingredients, and the individual cannabinoids have quite distinct biological activities requiring independent studies.
Clinical trials have confirmed its efficacy and tolerability. Other diseases in which different cannabinoids are currently being investigated include various pain states, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy. The continued characterization of individual cannabinoids in different diseases remains important. Cu doping concentration effect on the physical properties of CdS thin films obtained by the CBD technique.
Most traditional fabrication methods involve expensive vacuum processes including co-evaporation and sputtering techniques, where films and doping are conducted separately. On the other hand, the chemical bath deposition CBD technique allows an in situ process.
Cu-doped CdS thin films working as a buffer layer on solar cells provide good performing devices and they may be deposited by low cost techniques such as chemical methods. The elemental analysis and mapping reconstruction were conducted by EDXS. Morphological, optical and electrical properties were studied, and they revealed that Cu doping modified the CdS structure, band-gap value and the electrical properties.
Cu-doped CdS films show high resistivity compared to the non-doped CdS. Cannabidiol CBD , a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown.
All these findings report the inescapable role of this receptor in mediating CBD actions, here reported. CBD -enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. To describe the experience of five Israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil. A retrospective study describing the effect of cannabidiol CBD -enriched medical cannabis on children with epilepsy.
The selected formula contained CBD and tetrahydrocannabinol at a ratio of Seizure frequency was assessed by parental report during clinical visits. CBD treatment yielded a significant positive effect on seizure load.
In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep. Adverse reactions included somnolence, fatigue, gastrointestinal disturbances and irritability leading to withdrawal of cannabis use in 5 patients. The results of this multicenter study on CBD treatment for intractable epilepsy in a population of children and adolescents are highly promising.
Further prospective, well-designed clinical trials using enriched CBD medical cannabis are warranted. Published by Elsevier Ltd. Thin film CdS has been widely used in thin-film photovoltaic devices. Deregulating electricity in the American states. This dissertation develops nine stylized facts that summarize the major consequences of deregulation and tests these against recent experience in the electric utility industry.
The experience of the electric utility industry matches the predictions of the stylized facts, except in one instance: This dissertation presents three possible explanations for this discrepancy. First, through dynamic efficiency, consumers may benefit in the long run through lower rates and better service in the electricity market, or deregulation may be a public good that benefits electricity consumers through economy-wide improvements in efficiency.
Second, higher prices may be a long-run outcome as predicted by the theory of the second best. Or third, both regulators and utilities may use deregulation to generate new rents. Because the original rents from regulation had dissipated, new rents could be generated under deregulation by making consumers pay off the utilities and then creating more new rents through re-regulation of the industry.
Close examination tends to support the first and third explanations, although the second-best explanation cannot yet be ruled out completely. Higher prices appear to be a transitional phenomenon, resulting from a short-term payoff from consumers to incumbent utilities that was required to move deregulation forward.
This payoff occurs as residential and commercial consumers bear relatively higher rates over three to five years to compensate utilities for stranded costs, investments thought to be unrecoverable under full competition. All states are benefiting from deregulation , but states that are deregulating are benefiting less while stranded costs are being recovered. This dissertation also examines California electricity deregulation and finds that the experience in California conforms with to the stylized facts, and that certain structural.
Background Perturbations in intestinal microbiota composition have been associated with a variety of gastrointestinal tract-related diseases. The alleviation of symptoms has been achieved using treatments that alter the gastrointestinal tract microbiota toward that of healthy individuals. Identifying differences in microbiota composition through the use of 16S rRNA gene hypervariable tag sequencing has profound health implications. Current computational methods for comparing microbial communities are usually based on multiple alignments and phylogenetic inference, making them time consuming and requiring exceptional expertise and computational resources.
As sequencing data rapidly grows in size, simpler analysis methods are needed to meet the growing computational burdens of microbiota comparisons. Thus, we have developed a simple, rapid, and accurate method, independent of multiple alignments and phylogenetic inference, to support microbiota comparisons. Results We create a metric, called compression-based distance CBD for quantifying the degree of similarity between microbial communities.
CBD uses the repetitive nature of hypervariable tag datasets and well-established compression algorithms to approximate the total information shared between two datasets. Three published microbiota datasets were used as test cases for CBD as an applicable tool.
Conclusion CBD provides a simple, rapid, and accurate method for assessing distances between gastrointestinal tract microbiota 16S hypervariable tag datasets.
Perturbations in intestinal microbiota composition have been associated with a variety of gastrointestinal tract-related diseases. We create a metric, called compression-based distance CBD for quantifying the degree of similarity between microbial communities. CBD provides a simple, rapid, and accurate method for assessing distances between gastrointestinal tract microbiota 16S hypervariable tag datasets.
In the present work, nanocrystalline zinc oxide ZnO thin films have been successfully deposited onto glass substrates by simple and economical chemical bath deposition CBD and successive ionic layer adsorption reaction SILAR methods. These films were further characterized for their structural, optical, surface morphological and wettability properties. From optical studies, band gaps obtained are 2. Surface wettability studies show hydrophobic nature for both films. Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t 11;22 q24;q One key feature of oncogenic transformation is dysregulation of cell cycle control.
This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.
LPA- CBD an improved label propagation algorithm based on community belonging degree for community detection. In order to deal with stochasticity in center node selection and instability in community detection of label propagation algorithm, this paper proposes an improved label propagation algorithm named label propagation algorithm based on community belonging degree LPA- CBD that employs community belonging degree to determine the number and the center of community.
The general process of LPA- CBD is that the initial community is identified by the nodes with the maximum degree, and then it is optimized or expanded by community belonging degree. After getting the rough structure of network community, the remaining nodes are labeled by using label propagation algorithm.
The experimental results on 10 real-world networks and three synthetic networks show that LPA- CBD achieves reasonable community number, better algorithm accuracy and higher modularity compared with other four prominent algorithms.
Moreover, the proposed algorithm not only has lower algorithm complexity and higher community detection quality, but also improves the stability of the original label propagation algorithm. Prompt emergency medical service EMS system activation with rapid delivery of pre-hospital treatment is essential for patients suffering out-of-hospital cardiac arrest OHCA. We compared cardiac arrest call processing using these two dispatch tools in two different dispatch centres. Patients receiving CPR prior to call, interrupted calls or calls where the caller did not have access to the patients were excluded from analysis.
Dispatch logs, ambulance records and digitalized dispatcher and caller voice recordings were compared. The MPDS-site processed cardiac arrest calls and the CBD -site , of which and calls met the inclusion criteria, respectively.
Cannabis for Medical Purposes – Revised Reimbursement Policy
The FDA does not allow us to make any claims about what CBD Hemp Oil can do or Q7: When using the Vape Oil, how do I know how much CBD I'm getting?. 1 déc. Q7: When using the Vape Oil, how do I know how much CBD I'm getting? Restore Balance Naturally with Koi CBD's 0% THC products; CBD. Nabiximols / CBD in preparation with other cannabis-related .. CO2 Oil: cannabis extract obtained by supercritical carbon dioxide extraction. • Butane considered here as it has many similarities to cannabis extracts. Concentrates are being increasingly consumed using e-cigarettes and vape pens.