OTHER NAME(S). 2-[(1R,6R)Methylpropenylcyclohexenyl] pentylbenzene-1 ,3-diol, CBD. . Show More · Read Reviews (47). If you're considering trying CBD oil, it's important to discuss potential side effects and adverse reactions with your physician. In one study, for instance, children. CBD may help reduce symptoms related to cancer and side effects . Before you start using CBD oil, discuss it with your doctor to ensure your.
of Doctors Marijuana Effects Side CBD |
Sign up for a free Medical News Today account to customize your medical and health news experiences. Cannabidiol CBD may have some health benefits, and it may also pose risks. Products containing the compound are now legal in many American states where marijuana is not. This article will explain what CBD is, its possible health benefits, how to use it, potential risks, and issues surrounding its legality in the United States.
CBD is one of many compounds, known as cannabinoids, in the cannabis plant. Researchers have been looking at the possible therapeutic uses of CBD. The concentrations and the uses of these oils vary. THC creates a mind-altering "high" when a person smokes it or uses it in cooking. This is because THC breaks down when we apply heat and introduce it into the body. Unlike THC, it is not psychoactive. This means that CBD does not change a person's state of mind when they use it. However, CBD does appear to produce significant changes in the body, and some research suggests that it has medical benefits.
The least processed form of the cannabis plant is hemp. Hemp contains most of the CBD that people use medicinally. Hemp and marijuana come from the same plant, Cannabis sativa , but the two are very different.
Over the years, marijuana farmers have selectively bred their plants to contain high levels of THC and other compounds that interested them, often because the compounds produced a smell or had another effect on the plant's flowers. However, hemp farmers have rarely modified the plant.
These hemp plants are used to create CBD oil. The human body produces certain cannabinoids on its own. It also has two receptors for cannabinoids, called the CB1 receptors and CB2 receptors. The CB1 receptors in the brain deal with coordination and movement, pain, emotions, and mood, thinking, appetite, and memories, and other functions. THC attaches to these receptors. CB2 receptors are more common in the immune system. They affect inflammation and pain.
People tend to use prescription or over-the-counter drugs to relieve stiffness and pain, including chronic pain. Authors of a study published in the Journal of Experimental Medicine found that CBD significantly reduced chronic inflammation and pain in some mice and rats. The researchers suggested that the non-psychoactive compounds in marijuana, such as CBD, could provide a new treatment for chronic pain. Some promising evidence suggests that CBD use may help people to quit smoking.
A pilot study published in Addictive Behaviors found that smokers who used inhalers containing CBD smoked fewer cigarettes than usual and had no further cravings for nicotine. A similar review, published in Neurotherapeutics found that CBD may be a promising treatment for people with opioid addiction disorders. The researchers noted that CBD reduced some symptoms associated with substance use disorders. These included anxiety , mood-related symptoms, pain, and insomnia.
More research is necessary, but these findings suggest that CBD may help to prevent or reduce withdrawal symptoms. After researching the safety and effectiveness of CBD oil for treating epilepsy, the FDA approved the use of CBD Epidiolex as a therapy for two rare conditions characterized by epileptic seizures in The types of seizures that characterize LGS or DS are difficult to control with other types of medication.
The FDA specified that doctors could not prescribe Epidiolex for children younger than 2 years. A physician or pharmacist will determine the right dosage based on body weight. Authors of a review noted that CBD has anti-seizure properties and a low risk of side effects for people with epilepsy. Findings suggested that CBD may also treat many complications linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases.
Another study, published in Current Pharmaceutical Design, found that CBD may produce effects similar to those of certain antipsychotic drugs, and that the compound may provide a safe and effective treatment for people with schizophrenia. However, further research is necessary.
Some researchers have found that CBD may prove to combat cancer. Authors of a review published in the British Journal of Clinical Pharmacology found evidence that CBD significantly helped to prevent the spread of cancer.
The researchers also noted that the compound tends to suppress the growth of cancer cells and promote their destruction. They pointed out that CBD has low levels of toxicity. They called for further research into its potential as an accompaniment to standard cancer treatments. Doctors often advise people with chronic anxiety to avoid cannabis, as THC can trigger or amplify feelings of anxiousness and paranoia.
However, authors of a review from Neurotherapeutics found that CBD may help to reduce anxiety in people with certain related disorders. According to the review, CBD may reduce anxiety-related behaviors in people with conditions such as:.
The authors noted that current treatments for these disorders can lead to additional symptoms and side effects, which can cause some people to stop taking them. No further definitive evidence currently links CBD to adverse effects, and the authors called for further studies of the compound as a treatment for anxiety. Type 1 diabetes results from inflammation that occurs when the immune system attacks cells in the pancreas.
Research published in by Clinical Hemorheology and Microcirculation found that CBD may ease this inflammation in the pancreas. This may be the first step in finding a CBD-based treatment for type 1 diabetes.
A paper presented in the same year in Lisbon, Portugal, suggested that CBD may reduce inflammation and protect against or delay the development of type 1 diabetes. Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body.
A study published by the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body. Sebum is an oily substance, and overproduction can cause acne. Initial research published in the Journal of Alzheimer's Disease found that CBD was able to prevent the development of social recognition deficit in participants.
This means that CBD could help people in the early stages of Alzheimer's to keep the ability to recognize the faces of people that they know. This is the first evidence that CBD may slow the progression of Alzheimer's disease. Cannabis is legal for either medicinal or recreational use in some American states.
Other states have approved the use of CBD oil as a hemp product but not the general use of medical marijuana. Some state and federal laws differ, and current marijuana and CBD legislation in the U.
There is an ever-changing number of states that do not necessarily consider marijuana to be legal but have laws directly related to CBD oil. The following information is accurate as of May 8, , but the laws change frequently. However, state legislators generally approve the use of CBD oil at various concentrations to treat a range of epileptic conditions.
A full list of states that have CBD-specific laws is available here. Different states also require different levels of prescription to possess and use CBD oil. In Missouri, for example, a person can use CBD of a particular composition if they can show that three other treatment options have failed to treat their epilepsy.
Anyone considering CBD oil should speak with a local healthcare provider. They can provide information about safe CBD sources and local laws surrounding usage.
This is one of more than 80 active chemicals in marijuana. The new product was approved to treat seizures associated with two rare, severe forms of epilepsy in patients two years of age and older. Many small-scale studies have looked into the safety of CBD in adults.
They concluded that adults tend to tolerate a wide range of doses well. Researchers have found no significant side effects on the central nervous system , the vital signs, or mood, even among people who used high dosages. The most common side effect was tiredness. Also, some people reported diarrhea and changes in appetite or weight. Concerning the product that the FDA approved to treat two types of epilepsy, researchers noticed following adverse effects in clinical trials:.
The patient information leaflet notes that there is a risk of worsening depression or suicidal thoughts. It is important to monitor anyone who is using this drug for signs of mood change. Research suggests that a person taking the product is unlikely to form a dependency. There is often a lack of evidence regarding the safety of new or alternative treatment options. Usually, researchers have not performed the full array of tests. Anyone who is considering using CBD should talk to a qualified healthcare practitioner beforehand.
When drugs do not have FDA approval, it can be difficult to know whether a product contains a safe or effective level of CBD. Unapproved products may not have the properties or contents stated on the packaging. It is important to note that researchers have linked marijuana use during pregnancy to impairments in the fetal development of neurons.
Regular use among teens is associated with issues concerning memory, behavior, and intelligence. CBD-based products come in many forms. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. A study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance. Researchers suggest that CBD and other nonpsychoactive components of marijuana may represent a novel class of therapeutic agents for the treatment of chronic pain.
According to a meta-analysis conducted in Canada , the combination of CBD and THC buccal spray was found to be effective in treating neuropathic pain in multiple sclerosis , which can be debilitating for 50 percent to 70 percent of MS patients. It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs, as seen in using behavioral and neurochemical techniques in animal studies.
Additionally, studies show that CBD prevents human experimental psychosis and is effective in open case reports and clinical trials in patients with schizophrenia , with a remarkable safety profile. Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. A study aimed to compare the effects of a simulation public speaking test on healthy control patients and treatment-naive patients with social anxiety disorder.
A total of 24 never-treated patients with social anxiety disorder were given either CBD or placebo 1. Researchers found that pretreatment with CBD significantly reduced anxiety , cognitive impairment and discomfort in their speech performance, and significantly decreased alertness in anticipation of their speech. The placebo group presented higher anxiety, cognitive impairment and discomfort. A study published in the Journal of Pharmacology and Experimental Therapeutics found for the first time that CBD potently and selectively inhibited the growth of different breast tumor cell lines and exhibited significantly less potency in non-cancer cells.
In , researchers added light on the cellular mechanism through which CBD induces cell death in breast cancer cells. They showed that CBD induced a concentration-dependent cell death of both estrogen receptor-positive and estrogen receptor-negative breast cancer cells. They also found that the effective concentrations of CBD in tumor cells have little effect on non-tumorigenic, mammary cells. CBD behaves as a non-toxic compound and studies show that doses of milligrams per day for six weeks did not show any overt toxicity in humans, suggesting that it can be used for prolonged treatment.
Cannabis has been used for centuries for the suppression of nausea and vomiting. Research has revealed that among more than 80 cannabinoid compounds found in marijuana, both the intoxicant THC and the non-intoxicant CBD helps to get rid of nausea and vomiting in animal studies. Researchers found that CBD acts in a diphasic manner , meaning that in low doses it suppresses toxin-induced vomiting, but in high doses it increases nausea or has no effect.
Nineteen responses met the inclusion criteria for the study: The average number of anti-epileptic drugs tried before using CBD cannabis was Of these, two 11 percent reported complete seizure freedom, eight 42 percent reported a greater than 80 percent reduction in seizure frequency, and six 32 percent reported a 25—60 percent seizure reduction.
Other beneficial effects included increased alertness, better mood and improved sleep; while side effects included drowsiness and fatigue. After three months of treatment, 39 percent of the 23 patients had more than a 50 percent reduction in seizures, with a 32 percent median reduction. These preliminary results support the animal studies and survey reports that CBD may be a promising treatment for treatment-resistant epilepsy, and it is generally well-tolerated in doses up to 25 milligrams per kilogram of body weight.
A study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice. A histological examination of the pancreatic islets of the CBD-treated mice revealed significantly reduced insulitis.
In , the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin and insulin resistance among U. The study included 4, adult men and women from the National Health and Nutritional Examination Survey from to Of the participants, were current marijuana users and 1, were past users. The researchers found that current marijuana use was associated with 16 percent lower fasting insulin levels.
They also found significant associations between marijuana use and smaller waist circumferences, a factor connected to the onset of diabetes symptoms. A study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability which causes leaky gut associated with such environments.
As the popularity of CBD products continues to grow, more manufacturers are jumping on the bandwagon. This can be a great thing for consumers who are looking to get the best CBD products out there. But it also requires careful research before making a purchase. Although the research on the medicinal use of cannabis is strong, several studies indicate that the recreational use of cannabis can have persistent adverse effects on mental health.
Most recreational users will never be faced with such persistent mental illness, but in some individuals cannabis use leads to undesirable effects, including cognitive impairment, anxiety, paranoia and increased risks of developing chronic psychosis or drug addiction. Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports.
There are several ways to use CBD, including in capsule, topical, edible or drop forms. I recommend ingesting CBD oil using a dropper because this is the easiest way to stay in control of exactly how much you are taking.
Plus, pure CBD oil will not contain additives that come with side effects. Remember, when you are using CBD oil or any kind of cannabis product, you must read the product label to determine the best dose for you.
Where do you buy CBD oil? You may have noticed that CBD products are everywhere these days. To separate the highest quality products from the rest, look for one that has a certificate of analysis, or COA.
This means that the manufacture tests the product for contaminants, and it meets lab standards. I recommend avoiding vape pens because many contain a solvent called propylene glycol.
When you burn this solvent at high temperatures, it can degrade into formaldehyde and cause danger adverse reactions. CBD is one of over 60 compounds found in cannabis that belong to a class of ingredients called cannabinoids; it is the major nonpsychoactive component of Cannabis sativa.
Research shows that CBD benefits include its ability to act as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent.
It is a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia. CBD derived from industrial hemp is legal across the U. However, e ach state has specific requirements and conditions that need to be followed in order to use marijuana-derived CBD legally. Josh Axe is on a mission to provide you and your family with the highest quality nutrition tips and healthy recipes in the world The most common types of CBD available include: Tinctures are the most popular way to use CBD oil, likely because you can easily gauge exactly how much CBD you are ingesting.
A tincture is usually extracted using pressurized CO2 gas or a solvent. With a tincture, you use a dropper and place the drops under your tongue. These tend to be the most pure products. Sometimes, manufacturers will use carrier oils, natural flavors or fatty oils. Like tinctures, CBD concentrates are ingested by placing drops under your tongue. But concentrates are typically much stronger doses of CBD.
Like any other type of capsule, CBD capsules or pills can be taken with water. This is a convenient way to use CBD, but it gives you less control of the dose. Typically, capsules will contain 10—25 milligrams of CBD. Topical CBD products include lotions, salves and lip balms. CBD patches are also available for topical delivery of the compound. This allows the cannabinoids to be delivered directly to your bloodstream. CBD edibles, including chocolates, coffees, baked goods, gums and candies containing the compound, are becoming popular.
Although this may be a satisfying way to use CBD oil, it can be more difficult to measure exactly how much CBD you are ingesting and the results may be inconsistent. This requires the use of an e-cigarette or vape pen, which can have side effects when chemicals are heated to high temperatures. There are also CBD waxes available that are used for dabbing the cannabis compound. This also requires heating a small amount of the wax and using a dabbing pen.
Sprays are another product for using CBD internally.
Adverse Health Effects of Marijuana Use
Side effects of CBD include nausea, fatigue and irritability. If you decide to try CBD, talk with your doctor — if for no other reason than to make. These oils can be more potent than using dried marijuana, meaning What medical cannabis oil side effects are there, and how common are. CBD use also carries some risks. Though it's often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite.